Metadherin Polyclonal Antibody, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 40-650-0-Each-of-1 | In Stock | ₹ 44,500.00 |
40-650-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,500.00
GST (18%): ₹ 8,010.00
Total Price: ₹ 52,510.00
Antigen
Metadherin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MTDH
Gene Alias
2610103J23Rik; 3D3; 3D3/Lyric; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; AV353288; D8Bwg1112e; LYRIC; LYRIC/ MTDH; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; MTDH; Protein LYRIC
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
612147, 67154, 92140
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
0.25 mg/mL
Formulation
PBS with 0.1% sodium azide; pH 7.4
Gene Accession No.
Q80WJ7, Q86UE4
Gene Symbols
MTDH
Immunogen
Synthetic peptide derived from an internal region of the human, chimpanzee, mouse, and bovine metadherin (Mtdh, metastasis adhesion protein, LYsine-RIch CEACAM1 co-isolated (LYRIC), LYRIC/3D3, astrocyte elevated gene-1 (AEG-1)) protein, which differs from rat by one amino acid
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse, Non-human Primate
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells
- At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex
- Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue
- Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.