41-340-0
Ninein Monoclonal Antibody (79.160-7), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 41-340-0-Each-of-1 | In Stock | ₹ 40,050.00 |
41-340-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,050.00
GST (18%): ₹ 7,209.00
Total Price: ₹ 47,259.00
Antigen
Ninein
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.1% sodium azide; pH 7.4
Gene Accession No.
Q8N4C6
Gene Symbols
NIN
Immunogen
Synthetic peptide derived from an internal region of the human ninein protein
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Human, Non-human Primate
Product Type
Antibody
Isotype
IgG2a
Applications
ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
79.160-7
Conjugate
Unconjugated
Gene
NIN
Gene Alias
3110068G20Rik; AI385615; AU024711; glycogen synthase kinase 3 beta-interacting protein; GSK3B-interacting protein; hNinein; KIAA1565; mKIAA1565; Nin; Ninein; ninein (GSK3B interacting protein); ninein centrosomal protein; SCKL7
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
510366, 51199
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Ninein is a component of subdistal appendages of the mother centriole, localized specifically in the pericentriolar matrix of the centrosome
- It may be involved in microtubule minus-end capping, centriole positioning, and protein anchoring
- Recent studies have shown that the microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function
- At least five human ninein isoforms with divergent C-terminal domains and two mouse isoforms have been reported
- Data indicates that the combined action of domains (C-terminal and N-terminal) might, in the absence of coiled coil region, be sufficient to localize ninein to the mother centriole
- Microinjection of antibodies against ninein into metaphase HeLa cells can disrupt the reformation of tubular conformation of proteins within the centrosome following cell division, and consequently lead to dispersal of centrosomal material throughout the cytosol
- MTOC (microtubule organizing center) function can be disrupted when anti-ninein antibodies are injected into postmitotic cells
- Antibodies against ninein are present in sera from patients with autoimmune diseases that develop autoantibodies to centrosomal proteins.