4326104
FoxP3 Mouse anti-Human, Alexa Fluor 488, Clone: 259D/C7, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
FoxP3
Applications
Flow Cytometry
Conjugate
Alexa Fluor 488
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Description
Scurfin, IPEX, JM2
Clone
259D/C7
Classification
Monoclonal
Host Species
Mouse
Target Species
Baboon, Cynomolgus, Human, Rhesus Monkey
Immunogen
FoxP3 recombinant protein
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The 259D/C7 antibody reacts with the human FoxP3 transcription factor, a member of the forkhead or winged helix family of transcription factors
- The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ regulatory T cells and represents a specific marker for these cells
- Flow-cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of CD4+CD25int cell population are FoxP3 positive
- Approximately 5-10% of peripheral CD4+ cells are CD4+CD25+ T regulatory cells
- T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells
- To support this hypothesis, it has been found that FOXP3 is mutated in scurfy (sf) mice
- The 259D/C7 antibody reacts with all currently identified isoforms of human FoxP3 and is cross-reactive with Cynomolgus, Rhesus and Baboon.