4358232
CD27 Mouse anti-Human, Brilliant Violet 421, Clone: M-T271, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD27
Applications
Flow Cytometry
Conjugate
Brilliant Violet 421
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
TNFRSF7; TNF receptor superfamily, member 7; T14; Tp55; S152
Clone
M-T271
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human T-CLL cells
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The M-T271 monoclonal antibody specifically binds to CD27
- CD27 presents as a type I transmembrane, disulphide-linked 110 kDa homodimer comprised of two polypeptide chains
- The CD27 molecule is a lymphocyte-specific member of the TNF/NGF-R family, and is expressed on a subset of human thymocytes and on the majority of mature T lymphocytes, activated B cells and NK cells
- CD27 is highly induced on T cells after TCR stimulation
- CD27 binds to CD70 (also known as, CD27 ligand or CD27L) and may be involved in cellular interaction of T and B lymphocytes
- The antibody was conjugated to Brilliant Violet 421 and has been developed in collaboration with Sirigen
- With an Ex Max of 407-nm and Em Max at 421-nm, Brilliant Violet 421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter)
- Brilliant Violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates
- Host Species: Mouse Clone: M-T271 Isotype: IgG1, κ Species Reactivity: Human Flow Cytometry