Phospho-Syk (Tyr317) Polyclonal Antibody, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 44-233-G-Each | In Stock | ₹ 32,542.85 |
44-233-G - Each
In Stock
Quantity
1
Base Price: ₹ 32,542.85
GST (18%): ₹ 5,857.713
Total Price: ₹ 38,400.563
Antigen
Phospho-Syk (Tyr317)
Classification
Polyclonal
Formulation
Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
Gene Accession No.
P43405, P48025
Gene Symbols
Syk
Immunogen
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of mouse Syk that contains tyrosine 317 (tyrosine 323 in the human sequence).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Conjugate
Unconjugated
Gene
Syk
Gene Alias
DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20963, 6850
Content And Storage
-20°C
Form
Liquid
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Description
- Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases
- SYK may also play a role in cancer
- Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes
- Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases
- These kinases also help to activate Syk by phosphorylation of its activation loop.