4555624
p21WAF1 Ab-6 Mouse Monoclonal Antibody, Epredia™
Achieve accurate, reproducible results with the Epredia™ p21WAF1Ab-6, Mouse Monoclonal Antibody.
Manufacturer: Fischer Scientific
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Antigen
p21WAF1 Ab-6
Applications
Immunofluorescence, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Cancer and Tumor Biology
Immunogen
Human recombinant p21 protein
Primary or Secondary
Primary
Clone
HJ21; same as WA-1
Classification
Monoclonal
Form
Concentrated
Regulatory Status
RUO
Target Species
Human, Rat
Isotype
IgG1
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Description
- Description p21 WAF1 /Cip1/Sdi1/Pic1 is a tumor suppressor protein
- Expression of p21 WAF1 is induced by wild type, but not mutant, p53 suppressor protein
- The p21 WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression
- It also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process
- Host Species: Mouse Clone: HJ21; same as WA-1 Isotype: IgG1 Species Reactivity: Human and Rat
- Others not known
- Epitope: Not determined Immunogen: Human recombinant p21 protein Molecular Weight: 21kDa Positive Control: PC12, Ls174T or Raji cells Cellular Localization: Nuclear Recommended for: Immunohistochemistry (Not suitable) Western Blotting Immunofluorescence Immunoprecipitation (Not suitable) Flow Cytometry (Not Suitable) Note: USA: RUO; Int'l: RUO