Gata-3 Monoclonal Antibody (TWAJ), eFluor™ 450, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 48-996-642-Each-of-1 | In Stock | ₹ 37,825.00 |
48-996-642 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,825.00
GST (18%): ₹ 6,808.50
Total Price: ₹ 44,633.50
Antigen
Gata-3
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P23771, P23772
Gene Symbols
GATA3
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14462, 2625, 713840, 733631
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
TWAJ
Conjugate
eFluor 450
Gene
GATA3
Gene Alias
EGK_19445; GATA binding factor-3; GATA binding protein 3; GATA binding protein-3; GATA3; Gata-3; GATA-binding factor 3; GATA-binding protein 3; HDR; HDRS; jal; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3; Transacting T-cell-specific transcription factor GATA-3
Host Species
Rat
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human, Mouse, Porcine, Rhesus Monkey
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- The BMA12 monoclonal antibody reacts with mouse CD100, also known as Sema4D
- Sema4D/CD100 is a 150kDa transmembrane protein expressed constitutively on T cells and is involved in the activation of B cells through its interaction with CD72
- Interaction of these two proteins diminishes the negative signaling normally effected by CD72
- CD100 is already expressed strongly on resting T cells and somewhat weakly on B cells, but activation upregulates expression on both cell types
- Antigen expression has been reported in Spleen, thymus and l The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins
- Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes
- GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain
- GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages
- GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers
- Labastie et al
- (1994) cloned the human gene and the 5-prime end of the mouse gene
- The human gene comprises 6 exons distributed over 17 kb of DNA
- Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.