CD79a Monoclonal Antibody (24C2.5), eFluor™ 660, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-079-182-Each-of-1 | In Stock | ₹ 34,354.00 |
50-079-182 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,354.00
GST (18%): ₹ 6,183.72
Total Price: ₹ 40,537.72
Antigen
CD79a
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P11911
Gene Symbols
CD79A
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12518
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
24C2.5
Conjugate
eFluor 660
Gene
CD79A
Gene Alias
B-cell antigen receptor; B-cell antigen receptor complex-associated protein alpha chain; B-cell antigen receptor complex-associated protein alpha chain-like; CD79; CD79a; CD79A antigen (immunoglobulin-associated alpha); CD79a molecule; CD79a molecule, immunoglobulin-associated alpha; CD79A protein; CD79-alpha protein; EGK_10665; Ig alpha; IGA; Igalpha; ig-alpha; immunoglobulin-associated alpha; LOC100913063; Ly54; Ly-54; MB1; MB-1; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; surface IgM-associated protein
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- This 24C2.5 MAb reacts with the intracellular tail of mouse CD79a (also known as Ig alpha or mb-1), a signaling component of the B cell receptor (BCR)
- CD79a heterodimerizes with CD79b (Ig beta, B29), and together with surface Ig, make up the BCR
- Both CD79 subunits consist of a single extracellular Ig domain, a transmembrane domain, and an intracellular signaling domain
- CD79a is expressed almost exclusively on B cells, as well as in most B lineage acute lymphoblastic leukemias
- The cytoplasmic domain of CD79a contains immunoreceptor tyrosine-based activation motifs (ITAMs), which constitute the signal transducing portions of the BCR
- Tyrosine phosphorylation of these ITAMs by Syk and Lyn initiates numerous signaling cascades, resulting in B cell activation, proliferation, and differentiation
- CD79a is a disulphide-linked heterodimer that includes B29 (CD79b) polypeptide
- CD79a is a B lymphocyte antigen receptor with an antigen-specific surface component Ig (immunoglobulin) that associates with Ig-alpha and Ig-beta, necessary elements for the expression and function of the B-cell antigen receptor
- CD79a first appears at pre-B cell stage and persists until the plasma cell stage where it is found as an intracellular component
- CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas
- It is not present in myeloid or T cell lines
- Diseases associated with CD79a include Agammaglobulinemia 3 and Agammaglobulinemia, Non-Bruton type.