CD23 Monoclonal Antibody (B3B4), PE, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-102-71-Each-of-1 | In Stock | ₹ 11,392.00 |
50-102-71 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 11,392.00
GST (18%): ₹ 2,050.56
Total Price: ₹ 13,442.56
Antigen
CD23
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P20693
Gene Symbols
Fcer2a
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14128
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
B3B4
Conjugate
PE
Gene
Fcer2a
Gene Alias
BLAST-2; CD23; CD23 antigen; CD23A; CLEC4J; C-type lectin domain family 4 member J; C-type lectin domain family 4, member J; Fc epsilon receptor II; FC epsilon RII; Fc fragment of IgE receptor II; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc receptor alpha multiple ligand receptor; Fc receptor, IgE, low affinity II, alpha polypeptide; Fcalpha muR; Fcalpha RII; Fce2; fc-epsilon-RII; FCER2; Fcer2a; FceRII; IGEBF; Immunoglobulin E-binding factor; immunoglobulin epsilon-chain; low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; low-affinity IgE receptor; Ly-42; lymphocyte IgE receptor
Host Species
Rat
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
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Description
- Description: The B3B4 monoclonal antibody reacts with mouse CD23, a 45 kDa type II transmembrane glycoprotein
- CD23 is expressed on resting conventional B cells, and its expression is modulated upon B-cell activation
- B-1 cell lineage (CD5+ B cells) does not express CD23
- Soluble forms of the antigen have been reported to be biologically active
- CD23 is a low affinity receptor for IgE and is thought to play a role in the regulation of IgE response and B-cell activation
- CD21 is thought to bind to CD23
- Applications Reported: The B3B4 antibody has been reported for use in flow cytometric analysis
- Applications Tested: The B3B4 antibody has been tested by flow cytometric analysis of mouse splenocytes
- This can be used at less than or equal to 0.125 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser
- Filtration: 0.2 μm post-manufacturing filtered
- CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts
- The CD23 molecule is identical to the low affinity IgE receptor found on B cells
- Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma
- CD23 is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts
- Functionally, CD23 is involved in B cell growth and differentiation, and IgE production
- Further, CD23 has a soluble form that is a potent mitogenic factor
- Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.