Home Products Antibodies Primary Antibodies 50 107 48
50-107-48

CD305 (LAIR1) Monoclonal Antibody (113), PE, eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-107-48-Each-of-1 In Stock ₹ 15,664.00

50-107-48 - Each of 1

₹ 15,664.00

In Stock

Quantity

1

Base Price: ₹ 15,664.00

GST (18%): ₹ 2,819.52

Total Price: ₹ 18,483.52

Antigen

CD305 (LAIR1)

Classification

Monoclonal

Concentration

0.2 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

Q8BG84

Gene Symbols

LAIR1

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

52855

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

113

Conjugate

PE

Gene

LAIR1

Gene Alias

5133400O11Rik; BB115266; CD305; D7Bwg0421e; immunoglobulin heavy chain variable region; Lair1; Lair-1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; leukocyte-associated immunoglobulin-like receptor 1; rLAIR1

Host Species

Armenian Hamster

Quantity

50 μg

Primary or Secondary

Primary

Target Species

Mouse

Product Type

Antibody

Isotype

IgG

Description

  • Description: CD305 or Leukocyte-associated Ig-like receptor-1 (LAIR-1) is a 46 kD cell surface molecule that functions as an inhibitory collagen-receptor on the majority of cells of the immune system
  • The mouse LAIR-1 molecule is expressed primarily on monocytes/macrophages and also on T cells, NK cells and dendritic cells
  • Unlike human B cells , mouse B cells do not express LAIR-1
  • The cytoplasmic tail of mouse LAIR-1 can be phosphorylated leading to the recruitment of SH2-containing tyrosine phosphatase(SHP)-2 and C-terminal Src kinase
  • Applications Reported: This 113 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This 113 antibody has been tested by flow cytometric analysis of mouse splenocytes
  • This can be used at less than or equal to 0.25 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
  • Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser
  • Filtration: 0.2 μm post-manufacturing filtered
  • LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells
  • Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11
  • It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation
  • May also play its inhibitory role independently of SH2-containing phosphatases
  • Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta
  • Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion
  • Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells
  • Inhibits the differentiation of peripheral blood precursors towards dendritic cells.