50-111-07
TCL1 Monoclonal Antibody (eBio1-21 (1-21)), PE, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-111-07-Each-of-1 | In Stock | ₹ 33,731.00 |
50-111-07 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,731.00
GST (18%): ₹ 6,071.58
Total Price: ₹ 39,802.58
Antigen
TCL1
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P56279
Gene Symbols
TCL1A
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8115
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
eBio1-21 (1-21)
Conjugate
PE
Gene
TCL1A
Gene Alias
oncogene TCL1; Oncogene TCL-1; Protein p14 TCL1; T cell lymphoma breakpoint 1; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; T-cell leukemia/lymphoma protein 1A (P14 TCL1 protein) (TCL1 oncogene) (TCL-1 protein); T-cell lymphoma breakpoint 1; T-cell lymphoma-1; T-cell lymphoma-1A; TCL1; TCL-1; TCL1A
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- Description: The eBio1-21 antibody reacts with human T cell leukemia/lymphoma 1 (TCL1), a 14 kDa proto-oncogene product with a suggested role in intracellular regulation of T cell signalling
- TCL1 was identified as the oncogene located at the 14q32.1 chromosome breakpoint region in T-cell prolymphocytic leukemia (T-PLL)
- In T-PLL, TCL1 is overexpressed as a result of an inversion or a reciprocal translocation, by juxtaposition to the T-cell receptor promoter/enhancer elements
- TCL1 binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity
- By increasing Akt activity TCL1 may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3beta
- These substrates regulate cellular differentiation, growth, survival, and metabolism
- Besides its tumorigenic role in T-PLL, TCL1 is normally expressed in the CD3-CD4-CD8- subset of thymic precursors in the T cell lineage, the plasmacytoid subset of dendritic cells, stimulated (not resting) mature T cells, and B cells up to the germinal center stage of maturation
- TCL1 is inappropriately expressed by chromosome rearrangements that lead to pre-maligt clonal T cell expansions and mature T cell tumors
- TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia (CLL)
- Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements (summarized by Virgilio et al., 1998)
- In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation
- TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).