Blimp-1 Monoclonal Antibody (5E7), PE, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-2468-Each-of-1 | In Stock | ₹ 41,563.00 |
50-112-2468 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,563.00
GST (18%): ₹ 7,481.34
Total Price: ₹ 49,044.34
Antigen
Blimp-1
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q60636
Gene Symbols
PRDM1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12142
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
5E7
Conjugate
PE
Gene
PRDM1
Gene Alias
B lymphocyte-induced maturation protein 1; b2b1765Clo; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; Blimp1; BLIMP-1; B-lymphocyte-induced maturation protein 1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; Positive regulatory domain I-binding factor 1; PR domain 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PR/SET domain 1; PRDI BF1; PRDI-BF1; PRDI-binding factor-1; Prdm1; RP1-134E15.1; ZNFPR1A1
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
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Description
- Description: This 5E7 monoclonal antibody recognizes mouse B lymphocyte-induced maturation protein-1 (Blimp-1), which is also known as Prdm1
- Blimp-1 is a transcriptional repressor with five zinc finger domains
- Blimp-1 is expressed by terminally differentiating B and T cells
- Blimp-1 is also expressed by some dendritic cells, and some NK cells
- This transcriptional repressor is required for B cell differentiation into plasma cells and serves as a critical antagonist of CD4+ follicular helper T cell differentiation
- While Blimp-1 is not required for priming and development of T and B cell effector function, it is critical for effector cell terminal differentiation
- Blimp-1 promotes effector molecule secretion while suppressing proliferation
- Blimp-1 also acts as a transcriptional antagonist of Bcl-6 and inhibits genes that are related to memory cell differentiation
- Applications Reported: The 5E7 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: The 5E7 antibody has been tested by flow cytometric analysis of splenocytes isolated from sheep red blood cell-immunized mice
- This can be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus
- It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages
- Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells
- It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.