Desmin Monoclonal Antibody (DE-U-10), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-2816-Each-of-1 | In Stock | ₹ 40,584.00 |
50-112-2816 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,584.00
GST (18%): ₹ 7,305.12
Total Price: ₹ 47,889.12
Antigen
Desmin
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O62654, P02540, P02542, P17661, P31001, P48675
Gene Symbols
DES
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100328890, 100764990, 101097010, 101117308, 102180712, 13346, 1674, 280765, 395906, 396725, 64362
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
DE-U-10
Conjugate
Unconjugated
Gene
DES
Gene Alias
CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Chicken, Feline, Goat, Hamster, Human, Mouse, Ovine, Porcine, Rabbit, Rat
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The monoclonal antibody DE-U-10 recognizes desmin
- Desmin is the protein subunit of class-III intermediate filaments
- Desmin is found predomitly in skeletal, cardiac, and smooth muscle
- Desmin plays a role in muscle cell development and differentiation, muscle cell architecture and structure, and mitochondrial function
- Desmin forms scaffolds around the Z-disk of sarcomeres in muscle cells
- Desmin knockout mice exhibit defects in skeletal, smooth, and cardiac muscle and have impaired mitochondrial function
- Mutations in Desmin result in conditions such as desmin-related myopathy (DRM), cardiomyopathy dilated type 1I (CMD1I), and neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome)
- The DE-U-10 antibody recognizes human, mouse, rat, feline, bovine, goat, hamster, sheep, porcine, rabbit, and chicken desmin
- The DE-U-10 antibody will also label tumors derived from muscle tissue, such as leiomyomas and rhabdomyosarcomas
- Applications Reported: This DE-U-10 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry
- Applications Tested: This DE-U-10 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using either low or high pH antigen retrieval and can be used at less than or equal to 5 μg/mL
- Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle)
- Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation
- In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk
- The expression pattern of desmin in smooth muscle is much more heterogenous
- Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e
- rhabdomyosarcomas and leiomyosarcomas
- Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.