50-112-3211
Phospho-STAT4 (Tyr693) Monoclonal Antibody (4LURPIE), APC, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-3211-Each-of-1 | In Stock | ₹ 35,066.00 |
50-112-3211 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,066.00
GST (18%): ₹ 6,311.88
Total Price: ₹ 41,377.88
Antigen
Phospho-STAT4 (Tyr693)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P42228, Q14765
Gene Symbols
STAT4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20849, 6775
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
4LURPIE
Conjugate
APC
Gene
STAT4
Gene Alias
CIS4; HSPC060; OTTHUMP00000163553; Signal transducer and activator of transcription 4; SLEB11; SOCS4; SOCS6; SSI4; STAI4; STAT; Stat4; STATI4
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Description: This 4LURPIE monoclonal antibody recognizes human and mouse signal transducer and activator of transcription 4 (STAT4) when phosphorylated on tyrosine 693 (Y693)
- STAT proteins are activated by ligand binding to cytokine receptors that associate with Janus kinase (JAK) family members
- Following their phosphorylation by JAK proteins, STAT proteins translocate to the nucleus where they bind to DNA and regulate transcription of specific genes in a cell type- and cytokine-specific manner
- STAT4 is activated by IL-12 or type 1 IFN (IFN alpha, IFN beta)
- STAT4 is required for optimal Th1 differentiation in vivo
- Interestingly, although IFN alpha can lead to phosphorylation of STAT4 in mouse T cells, the phosphorylation is much weaker than that induced by IL-12 and is transient
- Thus, IFN alpha phosphorylation of STAT4 does not contribute to STAT4-mediated Th1 development or IFN gamma production by Th1 cells in mice
- In contrast, IFN alpha does promote Th1 development and function of human CD4+ T cells
- Specificity of this 4LURPIE clone was determined by ELISA and flow cytometry
- Applications Reported: This 4LURPIE antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This 4LURPIE antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of stimulated normal human peripheral blood cells
- This can be used at 5 μL (0.25 μg) per test
- Phospho-STAT4 (Tyr693) Monoclonal antibody specifically detects Phospho-STAT4 (Tyr693) in Human, Mouse samples
- It is validated for Flow Cytometry.