HLA-DQ Monoclonal Antibody (SK10), APC, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-3235-Each-of-1 | In Stock | ₹ 12,015.00 |
50-112-3235 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,015.00
GST (18%): ₹ 2,162.70
Total Price: ₹ 14,177.70
Antigen
HLA-DQ
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P01920
Gene Symbols
HLA-DQB1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3119
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
SK10
Conjugate
APC
Gene
HLA-DQB1
Gene Alias
BoLA-DQA; BOLA-DQA1; BOLA-DQA2; BOLA-DQA2 protein; BOLA-DQA3; BOLA-DQA5; BOLA-DQB; CELIAC1; HLA class II antigen; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA-DQB; HLA-DQB1; HLA-DRB1; IDDM1; lymphocyte antigen; major histocompatability complex class II; major histocompatibility complex, class II, DQ alpha 1 precursor; major histocompatibility complex, class II, DQ alpha 2; major histocompatibility complex, class II, DQ alpha 5; major histocompatibility complex, class II, DQ alpha, type 1; major histocompatibility complex, class II, DQ alpha, type 3; major histocompatibility complex, class II, DQ beta; major histocompatibility complex, class II, DQ beta 1; MHC class II antigen; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II antigen precursor; MHC class II DQ beta chain; MHC class II DQA; MHC class II DQA precursor; MHC class II DQA1 precursor; MHC class II DQA2 (BoLA-DQA2); MHC class II DQA2 precursor; MHC class II DQB precursor; MHC class II HLA-DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta; similar to MHC class II DQA2 (BoLA-DQA2); Unknown (protein for MGC:127488); Unknown (protein for MGC:137100)
Host Species
Mouse
Quantity
25 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: This SK10 monoclonal antibody reacts with the human MHC Class II HLA-DQ molecule
- This cell surface receptor is a heterodimeric protein composed of an alpha (HLA-DQA1) and beta (HLA-DQB1) subunit
- HLA-DQ is expressed on antigen presenting cells such as B cells, monocytes, macrophages, dendritic cells, and activated T cells
- HLA-DQ plays a role in presenting peptide antigens to CD4+ T lymphocytes
- Reports indicate that certain alleles of HLA-DQ are associated with celiac disease and type I diabetes
- Applications Reported: This SK10 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This SK10 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
- This can be used at 5 μL (0.5 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
- Filtration: 0.2 μm post-manufacturing filtered
- HLA-DQ is one of the HLA (human leukocyte antigen) molecules belonging to class II of the major histocompatibility protein (MHC) surface proteins
- HLA-DQ and the other MHC class II molecules are heterodimeric proteins consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane
- They play a central role in the immune system by presenting peptides derived from extracellular proteins
- MHC Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages) and present peptides endocytosed, digested, and loaded onto the proteins prior to their migration to the cell surface
- Other human MHC class II molecules are HLA-DP, HLA-DM, HLA-DR, HLA-DOA, and HLA-DOB
- HLA-DQ displays significant variability, particularly in the beta subunit within the region that affects the peptides bound and presented by the protein
- Different classes of DQ based on similar beta subunits allow for the grouping of these variants into serotypes, which can often be recognized by antibodies raised against these subunits
- HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.