CD257 (BAFF, BLyS) Monoclonal Antibody (1D6), PE, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-35-Each-of-1 | In Stock | ₹ 33,731.00 |
50-112-35 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,731.00
GST (18%): ₹ 6,071.58
Total Price: ₹ 39,802.58
Antigen
CD257 (BAFF, BLyS)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9Y275
Gene Symbols
TNFSF13B
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10673
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
1D6
Conjugate
PE
Gene
TNFSF13B
Gene Alias
ApoL related ligand TALL-1; b cell-activating factor; B lymphocyte stimulator; BAFF; B-cell-activating factor; B-lymphocyte stimulator; BLYS; CD257; D8Ertd387e; delta BAFF; Delta4 BAFF; dendritic cell-derived TNF-like molecule; DTL; RGD1561519; TALL1; TALL-1; THANK; TNF- and APOL-related leukocyte expressed ligand 1; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; Tnfsf13b; TNFSF20; TNLG7A; tumor necrosis factor (ligand) superfamily member 13b; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand 7A; tumor necrosis factor ligand superfamily member 13B; Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form; tumor necrosis factor superfamily member 13b; tumor necrosis factor-like protein ZTNF4; UNQ401/PRO738; ZTNF4
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The 1D6 monoclonal antibody reacts with human BLyS (B lymphocyte stimulator), also known as BAFF (B cell activating factor from the TNF family), TALL-1 (TNF and apoptosis leukocyte-expressed ligand-1), THANK (TNF homologue that activates apoptosis, nuclear factor KappaB and c-Jun NH2-terminal kinase) and zTNF4
- BLyS, a member of the TNF family, is a type II membrane protein that exists in both membrane-bound and soluble forms
- Expression of membrane-bound BLyS on monocytes lineage is regulated by IFN gamma
- BLyS acts as a potent B cell growth factor and costimulator of Ig production
- BLyS transgenic mice develop severe B cell hyperplasia and autoimmune lupus-like disease characterized by the presence of autoantibodies against nuclear antigens and immune complexes deposited in the kidney
- Data from animal models imply a role for BLyS in human autoimmune diseases
- To date BCMA, TACI and BR3 have been identified as receptors for BLyS
- APRIL, another TNF family member, and BLyS can form active heterotrimeric molecules when coexpressed and these circulating heterotrimers are present in serum samples from patients with systemic immune-based rheumatic diseases
- Furthermore, it has been reported that BLyS and APRIL, share BCMA and TACI as their receptors
- Applications Reported: The 1D6 antibody has been reported for use in flow cytometric analysis
- BAFF is a membrane bound cytokine expressed by B cell lineage cells
- The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR
- BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells
- BAFF is also expressed by T lymphocytes and has been shown to promote T cell activation and survival
- Isoforms representing alternatively spliced, and glycosylated variants have been identified.