AIRE Monoclonal Antibody (TM-724), eFluor™ 570, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-112-3644-Each | In Stock | ₹ 25,778.85 |
50-112-3644 - Each
In Stock
Quantity
1
Base Price: ₹ 25,778.85
GST (18%): ₹ 4,640.193
Total Price: ₹ 30,419.043
Antigen
AIRE
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O43918
Gene Symbols
Aire
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
326
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone
TM-724
Conjugate
eFluor 570
Gene
Aire
Gene Alias
Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a κ
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Description
- Description: This TM-724 monoclonal antibody reacts with human Autoimmune Regulator (AIRE)
- This 58 kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs)
- AIRE mRNA in the periphery has been observed in the lymph node, fetal liver, and intestines
- Furthermore, expression has been observed in dendritic cells, epithelial cells and PBMCs
- Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection
- Other biological functions for AIRE include chemokine expression and antigen presentation
- As a result of alternative splicing, three isoforms have been reported
- The conditions autoimmune-polyendocrinopathy-candiasis-ectodermal-dystrophy (APECED) and autoimmune polyglandular syndrome type 1 (APS-1) arise from mutations in the human AIRE gene
- The TM-724 antibody is predicted to recognize all three isoforms of human AIRE (AIRE-1, AIRE-2, AIRE-3)
- Applications Reported: This TM-724 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, immunohistochemical staining, and immunocytochemistry
- Applications Tested: This TM-724 antibody has been tested by immunohistochemistry on FFPE human thymus at less than or equal to 10 μg/mL using low pH antigen retrieval
- AIRE Monoclonal antibody specifically detects AIRE in Human samples
- It is validated for Immunocytochemistry, Immunohistochemistry (Paraffin).