50-112-4169
CD218a (IL-18Ra) Monoclonal Antibody (P3TUNYA), eFluor™ 450, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-4169-Each-of-1 | In Stock | ₹ 35,066.00 |
50-112-4169 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,066.00
GST (18%): ₹ 6,311.88
Total Price: ₹ 41,377.88
Antigen
CD218a (IL-18Ra)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q61098
Gene Symbols
Il18r1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16182
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
P3TUNYA
Conjugate
eFluor 450
Gene
Il18r1
Gene Alias
CD218 antigen-like family member A; CD218a; CDw218a; cytokine receptor; IL1 receptor-related protein; Il18r1; IL-18R1; IL-18R-1; IL18RA; Il18ralpha; IL-18R-alpha; IL18Ralpha2; IL1RRP; IL-1Rrp; IL1R-rp; interleukin 1 receptor related protein; interleukin 18 receptor 1; Interleukin-18; interleukin-18 receptor 1; Interleukin-18 receptor alpha
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
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Description
- Description: This P3TUNYA monoclonal antibody reacts with mouse CD218a (Interleukin 18 Receptor alpha)
- CD218a is one of the subunits of the heterodimeric receptor complex for the IL-18 cytokine
- IL-18 is a proinflammatory cytokine and member of the IL-1 family first identified by its role in IFN gamma secretion during toxic shock
- Like the other members of the family, it is synthesized as an inactive precursor which requires cleavage by caspases prior to secretion of the active form
- It is secreted by activated monocytes, macrophages, epithelial cells, and keratinocytes via a non-classical pathway
- IL-18 Receptor is expressed on Th1, but not naive CD4 T cells or Th2, as well as subsets of NK cells and neutrophils
- The heterodimeric receptor is made up of a ligand-binding alpha chain and signal-transducing beta chain
- On its own, IL-18Ra binds IL-18 with low affinity, although the affinity of this interaction increases upon forming a complex with IL-18Rb
- IL-18R signaling plays a critical role in Th1 differentiation and effector function, and results in the increased expression of IFN gamma, TNF alpha, and Fas ligand from T cells and NK cells
- IL-18 has also been found to synergize with IL-23 in the development and function of Th17 cells
- Recently, a subset of CD8 T cells has been discovered that co-secretes IFN gamma with IL-17A and sometimes IL-22
- These Tc17 cells share key transcription factors, chemokine receptors, and cytokine receptors with Th17 cells
- IL18R1 is a cytokine receptor that belongs to the interleukin 1 receptor family
- This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction
- IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells
- The gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.