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50-112-9097

CD366 (TIM3) Monoclonal Antibody (F38-2E2), PE-Cyanine7, eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each 50-112-9097-Each In Stock ₹ 14,475.85

50-112-9097 - Each

₹ 14,475.85

In Stock

Quantity

1

Base Price: ₹ 14,475.85

GST (18%): ₹ 2,605.653

Total Price: ₹ 17,081.503

Antigen

CD366 (TIM3)

Classification

Monoclonal

Concentration

5 μL/Test

Formulation

PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.

Q8TDQ0

Gene Symbols

Havcr2

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

84868

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

F38-2E2

Conjugate

PE-Cyanine7

Gene

Havcr2

Gene Alias

CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3

Host Species

Mouse

Quantity

25 Tests

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

Description

  • Description: This F38-2E2 monoclonal antibody reacts with human CD366, also known as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) or HAVCR2
  • This cell surface receptor is expressed on activated CD4+ T cell subsets (e.g
  • Th1, Th17, and Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells
  • Due to alternative splicing, CD366 exists as membrane-bound and soluble forms
  • Galectin-9 has been identified as the ligand for CD366
  • In humans, this receptor negatively regulates CD4+ T cells, influencing the secretion of some Th1- and Th17-related cytokines
  • CD366 has also been implicated in tolerance, autoimmune disease (e.g
  • multiple sclerosis), and HIV infection
  • Applications Reported: This F38-2E2 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This F38-2E2 antibody has been pre-titrated and tested by flow cytometric analyis of stimulated normal human peripheral blood cells
  • This can be used at 5 μL (0.06 μg) per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • Light sensitivity: This tandem dye is sensitive photo-induced oxidation
  • Please protect this vial and stained samples from light
  • Fixation: Samples can be stored in IC Fixation Buffer (cat
  • TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells
  • TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region
  • TIM3 is involved in macrophage activation and induction of autoimmune diseases
  • Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance
  • Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.