50-112-9113
IFN beta Monoclonal Antibody (A1 (IFNb)), Biotin, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-9113-Each-of-1 | In Stock | ₹ 33,286.00 |
50-112-9113 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,286.00
GST (18%): ₹ 5,991.48
Total Price: ₹ 39,277.48
Antigen
IFN beta
Classification
Monoclonal
Concentration
0.1 mg/mL
Formulation
TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
Gene Accession No.
P01574
Gene Symbols
Ifnb1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3456
Content And Storage
2-8°C
Form
Liquid
Applications
ELISA, Functional Assay, Western Blot
Clone
A1 (IFNb)
Conjugate
Biotin
Gene
Ifnb1
Gene Alias
Fibroblast interferon; Ifb; IFF; IFN b; IFN β; IFNB; Ifnb1; IFNbeta; IFN-beta; IFNβ; Interferon b; Interferon beta; interferon beta 1; interferon beta 1, fibroblast; interferon beta protein; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Description: The IFNb/A1 clone recognizes natural human IFN-beta and recombinants beta1a and beta1b
- It is capable of neutralizing IFN-beta
- Interferon beta is synthesized and secreted by fibroblasts and many other cell types in response to pathogens
- IFN-beta binding to type I interferon receptors induces the upregulation of IRF-7 and activation of Rnase L
- IRF-7 can exert a positive feedback on IFN-beta production
- RNase L cleaves both viral and cellular single stranded mRNA, thereby limiting viral replication and dissemination
- Applications Tested: ELISA, Neutralization tests, Western Blotting
- Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response
- IFNs can also inhibit the development of tumors
- IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes
- More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta
- IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.