50-112-9115
CD276 (B7-H3) Monoclonal Antibody (7-517), APC, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-9115-Each-of-1 | In Stock | ₹ 31,595.00 |
50-112-9115 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,595.00
GST (18%): ₹ 5,687.10
Total Price: ₹ 37,282.10
Antigen
CD276 (B7-H3)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q5ZPR3
Gene Symbols
CD276
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
80381
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
7-517
Conjugate
APC
Gene
CD276
Gene Alias
4Ig-B7-H3; 6030411F23Rik; AU016588; B7 homolog 3; B7h3; B7-H3; B7RP-2; CD276; CD276 antigen; CD276 molecule; CD276 molecule tv1; costimulatory molecule; PSEC0249; sB7 H3; sB7H3; sCD276; soluble B7 H3; soluble B7H3; soluble CD276; UNQ309/PRO352
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Description: This 7-517 monoclonal antibody reacts with human CD276, which is also known as B7-H3
- This type I transmembrane protein is expressed on immature and mature dendritic cells but not monocytes, granulocytes, or resting lymphocytes
- Moreover, CD276 is expressed on non-hematopoietic cells such as osteoblasts, fibroblasts, and epithelial cells
- However, CD276 expression can be induced on dendritic cells, monocytes, T, B, and NK cells
- This co-stimulatory molecule binds activated T cells, leading to cell proliferation and IFN-gamma production
- Applications Reported: This 7-517 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This 7-517 antibody has been pre-titrated and tested by flow cytometric analysis of normal human monocyte-derived dendritic cells
- This can be used at 5 μL (0.125 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
- Filtration: 0.2 μm post-manufacturing filtered
- CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3
- CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma
- Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon
- In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing
- CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.