RUNX1 Monoclonal Antibody (RXDMC), PE, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-9294-Each-of-1 | In Stock | ₹ 12,549.00 |
50-112-9294 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,549.00
GST (18%): ₹ 2,258.82
Total Price: ₹ 14,807.82
Antigen
RUNX1
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q01196, Q03347
Gene Symbols
RUNX1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12394, 861
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
RXDMC
Conjugate
PE
Gene
RUNX1
Gene Alias
acute myeloid leukemia 1 protein; Acute myeloid leukemia 2 protein; acute myeloid leukemia 3 protein; acute myeloid leukemia gene 2; AML1; AML-1; aml1 oncogene; AML1-EVI-1; AML1-EVI-1 fusion protein; AML2; AML3; AMLCR1; CBF2alpha; CBFA1; CBFA2; CBFA3; CBF-alpha 2; CBF-alpha-1; CBF-alpha-2; CBF-alpha-3; CCD; CCD1; CLCD; core binding factor alpha 2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); Core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; core-binding factor, runt domain, alpha subunit 3; EVI-1; Oncogene AML-1; oncogene AML-2; Oncogene AML-3; OSF2; OSF-2; osteoblast-specific transcription factor 2; OTTHUMP00000108697; OTTHUMP00000108700; OTTHUMP00000108702; PEA2 alpha C; PEA2aA; PEA2-alpha A; PEA2-alpha B; PEA2-alpha C; PEBP2 alpha C; PEBP2A; Pebp2a2; PEBP2A3; PEBP2aA; PEBP2aB; PEBP2aC; PEBP2alpha; PEBP2-alpha A; PEBP2-alpha B; PEBP2-alpha C; Pebpa2b; polyomavirus enhancer-binding protein 2 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; polyomavirus enhancer-binding protein 2 alpha C subunit; RUN1; runt domain, alpha subunit 2; runt related transcription factor 1; runt related transcription factor 2; runt related transcription factor 3; runt-related transcription factor 1; Runt-related transcription factor 2; runt-related transcription factor 3; Runx1; RUNX1/ZNF687 fusion; RUNX2; RUNX3; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; SL3/AKV core-binding factor alpha C subunit; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3-3 enhancer factor 1 alpha C subunit; transcription factor; transcription factor AML2
Host Species
Rat
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: This RXDMC monoclonal antibody reacts with human and mouse Runx1, which is also known as AML1
- This 50-kDa transcription factor is expressed in hematopoietic cells such as myeloid, T, and B cells, but not erythroid cells
- Furthermore, Runx1 can be detected in nearly all non-hematopoietic tissues except the brain and heart
- Runx1 is involved in several stages of T cell development, including the CD4-CD8- double negative (DN) to CD4+CD8+ double positive (DP) transition and commitment to the CD4 lineage
- In addition to its role in thymocyte development, Runx1 has also been implicated in Th2 differentiation and immune homeostasis via direct interaction with Foxp3 in CD4+CD25+ regulatory T cells
- Runx1 also affects Th2 differentiation by negatively regulating Gata-3 expression
- Finally, the AML1 gene, which encodes Runx1, is a frequent target of translocations in acute myeloid leukemia
- In humans, alternative splicing results in the generation of eleven isoforms
- In mice, five isoforms exist as a result of alternative splicing; isoform 4 (aka AML1-C) is the most highly expressed in hematopoietic cells
- Sequence analysis indicates that the RXDMC antibody recognizes isoform 4 in mouse and all human isoforms except AML-1FA, AML-1FB, and AML-1FC
- Applications Reported: This RXDMC antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- RUNX1 belongs to the mammalian RUNX family of DNA binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression
- RUNX1 is essential for hematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta
- RUNX1 is expressed in all tissues except brain and heart, with highest levels in thymus, bone marrow and peripheral blood.