CD56 (NCAM) Monoclonal Antibody (TULY56), eFluor™ 450, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-9760-Each-of-1 | In Stock | ₹ 25,632.00 |
50-112-9760 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,632.00
GST (18%): ₹ 4,613.76
Total Price: ₹ 30,245.76
Antigen
CD56 (NCAM)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P13591
Gene Symbols
Ncam1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4684, 693789
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
TULY56
Conjugate
eFluor 450
Gene
Ncam1
Gene Alias
adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human, Non-human Primate, Rhesus Monkey
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: This TULY56 monoclonal antibody reacts with human CD56, also known as Neural Cell Adhesion Molecule (NCAM)
- CD56 is a highly glycosylated transmembrane molecule expressed by neurons and plays a role in the homotypic adhesion of neural cells
- In the hematopoietic system, CD56 is expressed on NK cells and a subset of T cells referred to as NKT cells
- Staining with TULY56 does not block binding of CMSSB, suggesting that the two antibodies recognize different epitopes
- Additionally, TULY56 performs better after fixation and permeabilization than CMSSB
- The TULY56 monoclonal antibody crossreacts with Rhesus macaque
- Applications Reported: This TULY56 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This TULY56 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
- This can be used at 5 μL (0.125 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- eFluor™ 450 is an alternative to Pacific Blue™
- eFluor™ 450 emits at 445 nm and is excited with the Violet laser (405 nm)
- Please make sure that your instrument is capable of detecting this fluorochome
- Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser
- Filtration: 0.2 μm post-manufacturing filtered
- CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa
- CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity
- Polysialic modification results in reduction of CD56-mediated cell adhesion
- Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins
- CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma
- Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors
- Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.