Bcl-2 Monoclonal Antibody (Bcl2/100), FITC, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-113-7097-Each-of-1 | In Stock | ₹ 20,737.00 |
50-113-7097 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,737.00
GST (18%): ₹ 3,732.66
Total Price: ₹ 24,469.66
Antigen
Bcl-2
Classification
Monoclonal
Conjugate
FITC
Gene
Bcl2
Gene Alias
apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50
Host Species
Mouse
Purification Method
Size-exclusion chromatography
Regulatory Status
RUO
Gene ID (Entrez)
596
Content And Storage
4° C, store in dark
Form
Liquid
Applications
Flow Cytometry
Clone
Bcl2/100
Formulation
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.
P10415
Gene Symbols
Bcl2
Immunogen
Synthetic peptide corresponding to the amino acids 41-54 of human Bcl2
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death
- The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis
- Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2
- Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis
- Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells
- Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma
- In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative
- Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends
- The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.