TLR2 Monoclonal Antibody (2B4A1), PE, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-113-7689-Each-of-1 | In Stock | ₹ 36,223.00 |
50-113-7689 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,223.00
GST (18%): ₹ 6,520.14
Total Price: ₹ 42,743.14
Antigen
TLR2
Classification
Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with <0.1% sodium azide
Gene Accession No.
O60603, Q689D1
Gene Symbols
Tlr2
Immunogen
human Toll-like Receptor 2 (TLR2) from Recombinant TLR2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Canine, Human
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
2B4A1
Conjugate
PE
Gene
Tlr2
Gene Alias
CD282; Ly105; TIL4; Tlr2; TLR-2; toll like receptor 2; toll/interleukin-1 receptor-like protein 4; Toll-like receptor; toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; toll-like-receptor 2, exon 1a_; Toll-like-receptor, exon 1b; Toll-like-receptor, exon 1b_; Toll-like-receptor2, exon 1a
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
448807, 7097
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
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Description
- TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity
- TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B
- TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively
- TLRs are highly conserved from Drosophila to humans and share structural and functional similarities
- The various TLRs exhibit different patterns of expression
- TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB
- TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity
- Ten human homologs of TLRs (TLR1-10) have been described
- TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers
- CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells
- The expression of TLR2 on different cell types are regulated by different immune response modifiers
- For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.