50-113-7719
CD33 Monoclonal Antibody (WM53), PE-Cyanine5.5, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-113-7719-Each-of-1 | In Stock | ₹ 29,815.00 |
50-113-7719 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 29,815.00
GST (18%): ₹ 5,366.70
Total Price: ₹ 35,181.70
Antigen
CD33
Classification
Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with proprietary stabilizer and <0.1% sodium azide
Gene Accession No.
P20138
Gene Symbols
CD33
Immunogen
Human AML cells
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
WM53
Conjugate
PE-Cyanine5.5
Gene
CD33
Gene Alias
CD33; CD33 antigen; CD33 antigen (gp67); CD33 molecule; CD33 molecule transcript; FLJ00391; gp67; Myeloid cell surface antigen CD33; p67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC3; Siglec-3
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
945
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Related Products
Description
- CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family
- It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface
- CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia
- Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells
- CD33 is also expressed on, and is a useful marker for, peripheral monocytes
- CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias
- Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.