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50-138-08

CD200 Receptor Monoclonal Antibody (OX108), eBioscience™, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each 50-138-08-Each In Stock ₹ 12,072.85

50-138-08 - Each

₹ 12,072.85

In Stock

Quantity

1

Base Price: ₹ 12,072.85

GST (18%): ₹ 2,173.113

Total Price: ₹ 14,245.963

Antigen

CD200 Receptor

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

Q8TD46

Gene Symbols

CD200R1

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

131450

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry

Clone

OX108

Conjugate

Unconjugated

Gene

CD200R1

Gene Alias

antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; CD200 R1; CD200 receptor 1; CD200R; Cd200r1; Cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200; CRTR2; HCRTR2; MOX2 receptor; MOX2R; Orexin receptor 2; OX102 antigen; OX2 receptor; OX2R; UNQ2522/PRO6015

Host Species

Mouse

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

Description

  • Description: The monoclonal antibody OX108 recognizes human CD200R also known as OX2
  • CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors
  • Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways
  • In activated macrophages signaling results in inhibition of TNFalpha secretion
  • Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs
  • Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells
  • The epitope of OX108 is thought to be near the binding site of CD200
  • Applications Reported: This OX108 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This OX108 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells
  • This can be used at less than or equal to 0.5 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • CD200R (OX2R) is a receptor for the OX-2 membrane glycoprotein, and both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains
  • CD200R is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal
  • In mouse, CD200R is expressed primarily by peripheral blood monocytes and neutophils but also by other leucocytes including T-lymphocytes and mast cells
  • Further mouse studies of a gene related to CD200R suggests that the receptor may control myeloid function in a tissue-specific manner
  • Alternative splicing of CD200R results in multiple transcript variants
  • Diseases associated with CD200R dysfunction include primary hypertrophic osteoarthropathy.