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50-142-87

CD31 (PECAM-1) Monoclonal Antibody (390), Functional Grade, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

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Pack Size SKU Availability Price
Each of 1 50-142-87-Each-of-1 In Stock ₹ 34,354.00

50-142-87 - Each of 1

₹ 34,354.00

In Stock

Quantity

1

Base Price: ₹ 34,354.00

GST (18%): ₹ 6,183.72

Total Price: ₹ 40,537.72

Antigen

CD31 (PECAM-1)

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with no preservative; pH 7.2

Gene Accession No.

Q08481

Gene Symbols

Pecam1

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

18613

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry, Functional Assay

Clone

390

Conjugate

Functional Grade

Gene

Pecam1

Gene Alias

C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule

Host Species

Rat

Quantity

500 μg

Primary or Secondary

Primary

Target Species

Mouse

Product Type

Antibody

Isotype

IgG2a κ

Description

  • Description: The 390 monoclonal antibody reacts with mouse CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa
  • This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on all leukocytes and platelets
  • It has been reported that CD38 binds to CD31
  • Homotypic interaction of CD31 is important in adhesion, cell-cell and cell-matrix interaction, and signal transduction
  • Applications Reported: The 390 antibody has been reported for use in flow cytometric analysis
  • 390 has also been reported in in vitro functional studies
  • Applications Tested: The 390 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes
  • This can be used at less than or equal to 0.5 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
  • Storage and handling: Use in a sterile environment
  • Filtration: 0.2 μm post-manufacturing filtered
  • Purity: Greater than 90%, as determined by SDS-PAGE
  • Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay
  • Aggregation: Less than 10%, as determined by HPLC
  • CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases
  • CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells
  • N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions
  • CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis
  • It is one of key regulatory molecules in vascular system.