DLL1 (delta-like 1) Monoclonal Antibody (HMD1-5), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-145-69-Each-of-1 | In Stock | ₹ 56,248.00 |
50-145-69 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 56,248.00
GST (18%): ₹ 10,124.64
Total Price: ₹ 66,372.64
Antigen
DLL1 (delta-like 1)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
Q61483
Gene Symbols
DLL1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13388
Content And Storage
4° C
Form
Liquid
Applications
Functional Assay
Clone
HMD1-5
Conjugate
Functional Grade
Gene
DLL1
Gene Alias
C-Delta-1; Delta; delta like canonical Notch ligand 1; delta like-1; DELTA1; delta-like 1; delta-like 1 (Drosophila); delta-like protein 1; DL1; Dll1; Dll1-derived cell-associated form; Dll1-EC; Dll1-IC; Dll1-intracellular form; Dll1-soluble form; Dll1-TMIC; Drosophila Delta homolog 1; H-Delta-1; LOW QUALITY PROTEIN: delta-like protein 1; OTTHUMP00000017690; UNQ146/PRO172
Host Species
Armenian Hamster
Quantity
500 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Description: The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand
- Upon binding the Notch receptor (e.g
- Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase
- The second cleavage event releases an intracellular fragment whose biological function remains controversial
- Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen
- This protein is also expressed in nonhematopoietic tissues such as the lung and brain
- Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis
- This monoclonal antibody has been reported to have neutralizing activity
- Applications Reported: This HMD1-5 antibody has been reported for use in functional assays
- Applications Tested: This HMD1-5 antibody has been tested by flow cytometric analysis of Delta-like 1-transfected CHO cells
- This can be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Delta-like protein 1 (DLL1) is a transmembrane protein characterized by epidermal growth factor (EGF)-like repeats
- It is a ligand for Notch receptor
- It blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.