IFNAR1 Monoclonal Antibody (MAR1-5A3), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-146-44-Each-of-1 | In Stock | ₹ 49,662.00 |
50-146-44 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,662.00
GST (18%): ₹ 8,939.16
Total Price: ₹ 58,601.16
Antigen
IFNAR1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
P33896
Gene Symbols
Ifnar1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15975
Content And Storage
4° C
Form
Liquid
Applications
Functional Assay, Neutralization
Clone
MAR1-5A3
Conjugate
Functional Grade
Gene
Ifnar1
Gene Alias
alpha-type antiviral protein; AVP; beta-type antiviral protein; CD118; CRF2-1; cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; H3K1; Ifar; IFN R1; IFNalpha/beta R1; IFN-alpha/beta receptor 1; IFN-alpha/betaR; IFNalpha/betaR1; IFN-alpha/betaR1; IFN-alpha/betaRalpha; IFNalpha/beta-Ralpha; IFN-alpha-REC; IFNAR; Ifnar1; IFNBR; IFNR1; IFN-R-1; Ifrc; INF-a receptor; Infar; interferon (alpha and beta) receptor 1; interferon (alpha, beta and omega) receptor 1; interferon alpha and beta receptor subunit 1; interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; type I interferon receptor 1
Host Species
Mouse
Quantity
500 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The MAR1-5A3 monoclonal antibody reacts with mouse IFN alpha/beta receptor subunit 1 (IFNAR-1)
- The type I IFN receptor subunit 1 is co-expressed with IFNAR-2 on nearly all cells and make up the heterodimeric receptor complex that binds to all type I IFNs, IFN alpha and IFN beta
- Type I IFNs are a group of structurally and functionally related proteins that demonstrate antiviral, antiparasitic, and antiproliferative activities
- Applications Reported: The MAR1-5A3 antibody has been reported for use in neutralization of IFNAR1 bioactivity
- Applications Tested: The Functional Grade Purified MAR1-5A3 antibody has been tested by LAL assay to verify low endotoxin levels, by bioassay for neutralization of mouse IFNAR-1bioactivity
- The MAR1-5A3 antibody at 0.04 μg/mL has been found to inhibit by 50% the biological effects of 0.5 ng/mL mouse IFN-a2 (ND50), in an EMCV assay of L929 cell protection
- Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in Best Protocols® section
- Storage and handling: Use in a sterile environment
- Filtration: 0.2 μm post-manufacturing filtered
- Purity: Greater than 90%, as determined by SDS-PAGE
- Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay
- Aggregation: Less than 10%, as determined by HPLC
- Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002)
- These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1)
- Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling
- This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).