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50-147-01

IL-5 Monoclonal Antibody (TRFK5), Functional Grade, eBioscience™, Invitrogen™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-147-01-Each-of-1 In Stock ₹ 34,265.00

50-147-01 - Each of 1

₹ 34,265.00

In Stock

Quantity

1

Base Price: ₹ 34,265.00

GST (18%): ₹ 6,167.70

Total Price: ₹ 40,432.70

Antigen

IL-5

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with no preservative; pH 7.2

Gene Accession No.

P04401, P05113

Gene Symbols

Il5

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

16191, 3567

Content And Storage

4° C

Form

Liquid

Applications

Functional Assay, Immunohistochemistry, Immunostaining, Neutralization

Clone

TRFK5

Conjugate

Functional Grade

Gene

Il5

Gene Alias

B-cell differentiation factor I; B-cell growth factor II; BCGF-II; colony-stimulating factor, eosinophil; cytotoxic T-lymphocyte inducer; EDF; Eosinophil differentiation factor; IL5; IL-5; ILN; Interleukin; Interleukin 5; Interleukin 5 (colony-stimulating factor eosinophil); Interleukin 5 (colony-stimulating factor, eosinophil); Interleukin5; interleukin-5; T-cell replacing factor; TRF

Host Species

Rat

Quantity

500 μg

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG1

Description

  • Description: The TRFK5 antibody reacts with mouse and human interleukin-5 (IL-5)
  • The TRFK5 antibody is a neutralizing antibody
  • Mouse IL-5 is a disulfide-linked homodimer, containing two 113 amino acid peptides; these resolve as 32-34 kDa bands in SDS-PAGE
  • IL-5 is produced by T cells and has been known as eosinophil-differentiating factor (EDF), B cell growth factor II (BCGFII), and T cell-replacing factor (TRF)
  • IL-5 induces eosinophil differentiation and promotes eosinophil survival and activation
  • In mice, IL-5 has been shown to stimulate B cell proliferation and antibody production
  • Applications Reported: The TRFK5 antibody has been reported for use in ELISA capture, ELISPOT capture, neutralization of IL-5 bioactivity, and IHC
  • Applications Tested: The Functional Grade Purified TRFK5 antibody has been tested by LAL assay to verify low endotoxin levels, by ELISA, and in bioassay for neutralization of mouse IL-5 bioactivity
  • The TRFK5 antibody at 0.06 μg/mL has been found to inhibit by 50% the biological effects of 1.0 ng/mL mouse IL-5 in an MC/9 cell proliferation assay
  • Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols™ section
  • IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils
  • IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation
  • The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes
  • The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF)
  • IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5
  • IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.