CD267 (TACI) Monoclonal Antibody (ebio8F10-3), APC, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-152-60-Each-of-1 | In Stock | ₹ 20,292.00 |
50-152-60 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,292.00
GST (18%): ₹ 3,652.56
Total Price: ₹ 23,944.56
Antigen
CD267 (TACI)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9ET35
Gene Symbols
TNFRSF13B
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
57916
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
ebio8F10-3
Conjugate
APC
Gene
TNFRSF13B
Gene Alias
1200009E08Rik; CD267; CVID; CVID2; IGAD2; NEWGENE_1595998; RYZN; TACI; TNF receptor superfamily member 13B; Tnfrsf13b; TNFRSF14B; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: The monoclonal antibody eBio8F10.3 recognizes TACI (Transmembrane Activator and Calcium-modulator and CAML Interactor) also known as CD267
- TACI is a type III membrane protein belonging to the TNF receptor superfamily
- The ligand for TACI has been shown to be BAFF (BLyS) and APRIL
- TACI is expressed on the surface of a subset of maturing splenic B cells of the transitional type termed T2
- Genetic studies have shown a role for TACI in both stimulation and inhibition of B cell proliferation
- This actual role for TACI in the mouse has still not been determined
- Recently human TACI has been shown to have repressive activities which inhibit BAFF-R function
- Applications Reported: This ebio8F10-3 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This ebio8F10-3 antibody has been tested by flow cytometric analysis of mouse splenocytes
- This can be used at less than or equal to 0.25 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
- Filtration: 0.2 μm post-manufacturing filtered
- Members in the TNF superfamily regulate immune responses and induce apoptosis
- Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively
- BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion
- April regulates immunological and non-immunological cell growth
- Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified
- TACI, like BCMA, binds BAFF and April
- TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.