50-155-6721
Phospho-BRCA1 (Ser1524) Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Manufacturer: Bethyl Laboratories, Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-155-6721-Each-of-1 | In Stock | ₹ 46,362.77 |
50-155-6721 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,362.77
GST (18%): ₹ 8,345.299
Total Price: ₹ 54,708.069
Antigen
Phospho-BRCA1 (Ser1524)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BRCA1
Gene Alias
Breast Cancer 1, Breast Cancer 1 Early Onset, Breast Ovarian Cancer Susceptibility, IRIS, Papillary Serous Carcinoma Of The Peritoneum, PSCP, RNF53
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
672
Content And Storage
4° C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/ml
Formulation
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.
P38398
Gene Symbols
BRCA1
Immunogen
Surrounding serine 1524
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Gorilla and Chimpanzee BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex)
- BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex
- The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination
- Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers
- Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene
- Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described
- A related pseudogene, which is also located on chromosome 17, has been identified.