50-155-7651
MSH2 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories
Manufacturer: Bethyl Laboratories, Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-155-7651-Each-of-1 | In Stock | ₹ 43,546.81 |
50-155-7651 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,546.81
GST (18%): ₹ 7,838.426
Total Price: ₹ 51,385.236
Antigen
MSH2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MSH2
Gene Alias
COCA1, FCC1, HNPCC, HNPCC1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17685, 4436
Content And Storage
4° C
Form
Liquid
Applications
Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration
1 mg/ml
Formulation
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.
P43246, P43247
Gene Symbols
MSH2
Immunogen
Between 875 and C-term
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC)
- CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations
- These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired
- Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC
- hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA.