UBAP2L/NICE4 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse NICE4, also known as UBAP2L (Ubiquitin-associated protein 2-like) orKIAA0144, is a 1,087 amino acid protein that is ubiquitously expressed
• Phosphorylated upon DNA damage, NICE4 contains one UBA domain and is expressed as 4 isoforms produced by alternative splicing events
• The gene that encodes NICE4 maps to human chromosome 1
• Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome
• There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1
• Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A
• When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs
• The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration
• The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis
• Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.