COMMD1 Mouse anti-Human, Clone: OTI2E2, liquid, TrueMAB™

Description

• Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins
• Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activiy and dissocoiates CAND1 from CUL1 and CUL2
• Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation
• Down-regulates NF-kappa-B activity
• Involved in the regulation of membrane expression and ubiquitination of SLC12A2
• Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L
• Promotes the localization of SCNN1D to recycling endosomes
• Promotes CFTR cell surface expression through regulation of its ubiquitination
• Down-regulates SOD1 activity by interfering with its homodimerization
• Plays a role in copper ion homeostasis
• Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes
• Can bind one copper ion per monomer
• May function to facilitate biliary copper excretion within hepatocytes
• Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2)
• Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1.