50-167-6629
CD22 Mouse anti-Canine, Human, Mouse, Rat, Clone: OTI4C3, liquid, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-6629-Each-of-1 | In Stock | ₹ 20,470.00 |
50-167-6629 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,470.00
GST (18%): ₹ 3,684.60
Total Price: ₹ 24,154.60
Antigen
CD22
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
P20273, P35329
Gene Symbols
CD22
Immunogen
Full length human recombit protein of human CD22 produced in HEK293T cell.
Quantity
30 μL
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI4C3
Conjugate
Unconjugated
Gene
CD22
Gene Alias
SIGLEC-2, SIGLEC2
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12483, 308501, 476485, 933
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140 kDa
- CD22 is expressed in both the cytoplasm and cell membrane of B-lymphocytes
- CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen
- Unlike other B-cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias
- CD22 is also strongly expressed in hairy cell leukemia
- CD22 preferentially binds to alpha2,6-linked sialic acid
- The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface
- Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling
- CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules
- CD22 is also strongly expressed in hairy cell leukemia
- CD22 is also positive in diffuse large B-cell lymphoma and nodular lymphocyte predomice Hodgkin′s lymphoma, but negative in classical Hodgkin′s lymphoma.