50-167-6650
TNFA Monoclonal Antibody (OTI1H3), TrueMAB™, OriGene
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-6650-Each-of-1 | In Stock | ₹ 44,954.79 |
50-167-6650 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,954.79
GST (18%): ₹ 8,091.862
Total Price: ₹ 53,046.652
Antigen
TNFA
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
P01375
Gene Symbols
TNF
Immunogen
Full length human recombit protein of human TNF produced in HEK293T cell.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
Western Blot
Clone
OTI1H3
Conjugate
Unconjugated
Gene
TNF
Gene Alias
DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
7124
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily
- This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR
- TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation
- TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions
- Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice
- Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors
- TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity
- This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.