50-167-6655
SNCA Mouse anti-Human, Clone: OTI2F6, liquid, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-6655-Each-of-1 | In Stock | ₹ 44,954.79 |
50-167-6655 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,954.79
GST (18%): ₹ 8,091.862
Total Price: ₹ 53,046.652
Antigen
SNCA
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
P37840
Gene Symbols
SNCA
Immunogen
Full length human recombit protein of human SNCA produced in HEK293T cell.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI2F6
Conjugate
Unconjugated
Gene
SNCA
Gene Alias
NACP, PARK1, PARK4, PD1
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6622
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- Alpha-Synuclein belongs to the Synuclein family, which includes beta and gamma Synuclein, and is predomitly expressed in neurons, and concentrated at synaptic terminals
- Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function
- Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies
- Alpha-Synuclein is involved in the formation of SNARE complexes, and most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson′s disease (PD) and other neurodegenerative disorders
- Mutation of the alpha-synuclein gene is associated with familial forms of PD
- Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1
- The alpha and beta synucleins are found primarily in brain tissue where they are seen mainly in neuronal cytosol and presynaptic terminals.