50-167-7286
ENG Mouse anti-Human, Clone: OTI3H5, liquid, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-7286-Each-of-1 | In Stock | ₹ 46,061.06 |
50-167-7286 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,061.06
GST (18%): ₹ 8,290.991
Total Price: ₹ 54,352.051
Antigen
ENG
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with <5% trehalose and 0.05% sodium azide
Gene Accession No.
P17813
Gene Symbols
ENG
Immunogen
Full length human recombit protein of human ENG produced in HEK293T cell.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA
Clone
OTI3H5
Conjugate
Unconjugated
Gene
ENG
Gene Alias
END, HHT1, ORW1
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2022
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- CD105 (Endoglin is a Type I transmembrane protein) is highly expressed on human vascular endothelial cells and exists on an O- and N-glycosylated homodimer
- Up regulation of CD105 expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker
- CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumors and its gene expression is stimulated by hypoxia
- CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2
- Mutations in the CD105 gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal domit multisystemic vascular dysplasia
- Alternatively spliced transcript variants encoding different isoforms of CD105 have been found
- Diseases associated with CD105 dysfunction include hereditary hemorrhagic telangiectasia.