50-167-7984
PCNA Mouse anti-Human, Biotin, Clone: OTI1H10, liquid, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-7984-Each-of-1 | In Stock | ₹ 49,681.58 |
50-167-7984 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,681.58
GST (18%): ₹ 8,942.684
Total Price: ₹ 58,624.264
Antigen
PCNA
Clone
OTI1H10
Conjugate
Biotin
Gene
PCNA
Gene Alias
ATLD2
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5111
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 10mg/ml BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
P12004
Gene Symbols
PCNA
Immunogen
Full length human recombit protein of human PCNA produced in HEK293T cell.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
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Description
- PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways
- PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT)
- PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e
- relevant to prognosis)
- PCNA is a marker for cells in early G1 phase and S phase of the cell cycle
- PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication
- In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway
- Two transcript variants encoding the same protein have been found for PCNA
- Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.