50-167-8025
USP12 Monoclonal Antibody (OTI2A6), TrueMAB™, OriGene
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-167-8025-Each-of-1 | In Stock | ₹ 44,954.79 |
50-167-8025 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,954.79
GST (18%): ₹ 8,091.862
Total Price: ₹ 53,046.652
Antigen
USP12
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
O75317
Gene Symbols
USP12
Immunogen
Human recombit protein fragment corresponding to amino acids 61-251 of human USP12 produced in E.coli.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Western Blot
Clone
OTI2A6
Conjugate
Unconjugated
Gene
USP12
Gene Alias
UBH1, USP12L1
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
219333
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- Modification of target proteins by ubiquitin participates in a wide array of biological functions
- Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin
- However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity
- An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families
- Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes
- Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution
- USPs tend to release ubiquitin from a conjugated protein
- They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.