50-168-4895
PECAM1 Mouse anti-Human, Clone: UMAB31, liquid, UltraMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-168-4895-Each-of-1 | In Stock | ₹ 56,721.48 |
50-168-4895 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 56,721.48
GST (18%): ₹ 10,209.866
Total Price: ₹ 66,931.346
Antigen
PECAM1
Classification
Monoclonal
Concentration
0.5-1.0 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
P16284
Gene Symbols
PECAM1
Immunogen
Full length human recombit protein of human PECAM1 produced in HEK293T cell.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
UMAB31
Conjugate
Unconjugated
Gene
PECAM1
Gene Alias
CD31, CD31/EndoCAM, GPIIA′, PECA1, PECAM-1, endoCAM
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5175
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases
- CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells
- The N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions
- Further, CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis
- CD31 is one of key regulatory molecules in the vascular system
- CD31 induces susceptibility to atherosclerosis and this cell adhesion molecule is required for leukocyte migration under most inflammatory conditions
- Antibodies to CD31 is of value in the study of benign and maligt vascular tumors.