50-172-6726
Cyclin D2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-172-6726-Each-of-1 | In Stock | ₹ 44,150.23 |
50-172-6726 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
Cyclin D2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CCND2
Gene Alias
CCND2, cyclin D2, G1/S-specific cyclin-D2
Host Species
Rabbit
Purification Method
Antigen Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12444, 894
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
0.3 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.
P30279, P30280
Gene Symbols
CCND2
Immunogen
Cyclin D2 Fusion Protein Ag1377
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
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Description
- Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition
- Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase
- Hypophosphorylates RB1 in early G1 phase
- Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals
- Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity
- Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.