50-172-7237
UCHL5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-172-7237-Each-of-1 | In Stock | ₹ 44,150.23 |
50-172-7237 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
UCHL5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
UCHL5
Gene Alias
CGI 70, INO80R, Ubiquitin thioesterase L5, UCH L5, UCH37, UCHL5
Host Species
Rabbit
Purification Method
Antigen Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
360853, 51377, 56207
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.13 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.
Q9WUP7, Q9Y5K5
Gene Symbols
UCHL5
Immunogen
UCHL5 Fusion Protein Ag2095
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates
- Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth
- Through associations with Smad7, UHC-L5 can dramatically upregulate TGFbeta-dependent gene expression by de-ubiquinating and stabilizing TGFbeta RI
- Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment
- There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.