50-173-3999
ZRANB3 Rabbit anti-Human, Polyclonal, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-173-3999-Each-of-1 | In Stock | ₹ 44,150.23 |
50-173-3999 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
ZRANB3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ZRANB3
Gene Alias
ZRANB3
Host Species
Rabbit
Purification Method
Antigen Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
84083
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.35 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q5FWF4
Gene Symbols
ZRANB3
Immunogen
ZRANB3 Fusion Protein Ag19407
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
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Description
- TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors
- TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin
- Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway
- TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors
- Interaction between TSC1 and TSC2 may facilitate vesicular docking
- TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth
- Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma
- Alternative splicing results in transcript variants of three different isoforms of TSC2.