50-173-4590
TREX1 Rabbit anti-Human, Polyclonal, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-173-4590-Each-of-1 | In Stock | ₹ 44,150.23 |
50-173-4590 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
TREX1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TREX1
Gene Alias
3 5 exonuclease TREX1, AGS1, AGS5, CRV, DNase III, DRN3, HERNS, TREX1
Host Species
Rabbit
Purification Method
Antigen Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11277
Content And Storage
-20°C
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Concentration
0.35 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.
Q9NSU2
Gene Symbols
TREX1
Immunogen
TREX1 Fusion Protein Ag18325
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease which is required for checkpoint signaling after DNA damage
- It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress
- Trex1 is required for ATR expression
- This gene uses two different open reading frames
- The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint
- The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity and may be a subunit of human DNA polymerase III
- Multiple transcript variants encoding different isoforms have been found
- Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.