CD50 (ICAM-3) Monoclonal Antibody (CBR-IC3/1), eBioscience™, Invitrogen™

Description

• Description: Intercellular Adhesion Molecule-3 (ICAM-3) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1)
• ICAM-3 is a heavily glycosylated, integral membrane protein with five immunoglobulin-like domains
• It shares high homology to ICAM-1 and ICAM-2 in the extracellular region
• In contrast to ICAM-1 and ICAM-2, ICAM-3 is absent on endothelia
• ICAM-3 is expressed on resting lymphocytes, monocytes and neutrophils, representing the major LFA-1 ligand on these cells
• The finding that adhesion of resting T lymphocytes to LFA-1 occurs primarily via ICAM-3 combined with the fact that ICAM-3 is much better expressed than other LFA-1 ligands on monocytes and resting lymphocytes implies an important role for ICAM-3 in the initiation of immune responses
• Applications Tested: ELISA, Flow Cytometry, Functional Studies (Blocking), Immunohistochemistry
• Purity: >95%
• CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin
• Besides functioning as an adhesive molecule that mediates e.g
• the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation
• ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.