CD62L (L-Selectin) Monoclonal Antibody (DREG.55), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-177-65-Each-of-1 | In Stock | ₹ 25,810.00 |
50-177-65 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,810.00
GST (18%): ₹ 4,645.80
Total Price: ₹ 30,455.80
Antigen
CD62L (L-Selectin)
Classification
Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with no preservative; pH 7.2-7.4
Gene Accession No.
P14151
Gene Symbols
SELL
Immunogen
Rec. Human CD62L (L-selectin)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Flow Cytometry, Immunohistochemistry (Frozen)
Clone
DREG.55
Conjugate
Unconjugated
Gene
SELL
Gene Alias
A.11; AI528707; CD62 antigen-like family member L; CD62L; gp90-MEL; hLHRc; LAM1; LAM-1; LECAM1; LECAM-1; LEU8; Leu-8; Leukocyte adhesion molecule 1; leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LSEL; L-selectin; Ly22; Ly-22; LYAM1; Lyam-1; Ly-m22; Lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; pln homing receptor; PLNHR; SELE; selectin E (endothelial adhesion molecule 1); selectin L; selectin L (lymphocyte adhesion molecule 1); selectin, lymphocyte; Sell; TQ1
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
6402
Content And Storage
4° C
Form
Liquid
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Description
- Description: The antibody can be used to stain acetone-fixed cryostat sections or cell smears
- BMS121 is not suitable for paraffin sections but is suitable as primary antibody in staining for FACS analysis
- BMS121FI can be used for direct staining of cells, BMS121BT can be used in a 2-step procedure using the biotin-(strept)avidin system
- BMS121 has not been tested in functional assays but is suitable for ELISA application
- Leukocyte-Endothelial Cell Adhesion Molecule-1 belongs to the selectin family of adhesion molecule
- Together with E-selectin, P-selectin and L-selectin mediates the initial interactions of leukocytes with endothelial cells
- Selectins guide non-activated polymorphonuclear cells to the areas of inflammation in creating first, loose contacts with the endothelial layer
- L-selectin in this aspect mediates rolling of PMN's on endothelial cells
- The potential binding partners of L-selectin carry a negative charge, probably a sialic acid and/or sulphate, and may contain mannose and fucose
- In addition, L-selectin may also interact with E-selectin which is expressed on cytokine-activated endothelial cells
- L-selectin is constitutively expressed on most leukocytes in a seemingly functional form
- It is required for the binding of lymphocytes to the high endothelial venules of peripheral lymph nodes and for the invasion of neutrophils into sites of inflammation
- The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors
- L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region
- Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.