50-177-86
CD126 Monoclonal Antibody (B-R6), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-177-86-Each-of-1 | In Stock | ₹ 21,449.00 |
50-177-86 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 21,449.00
GST (18%): ₹ 3,860.82
Total Price: ₹ 25,309.82
Antigen
CD126
Classification
Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P08887
Gene Symbols
IL6R
Immunogen
Rec. Human IL-6R (CD126)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Functional Assay
Clone
B-R6
Conjugate
Unconjugated
Gene
IL6R
Gene Alias
CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL6Q; IL6R; IL-6R; IL-6R 1; IL-6R subunit alpha; IL6R1; IL-6R-1; Il6ra; IL-6RA; IL-6R-alpha; IL6RQ; ILN; Interleukin; interleukin 6 receptor; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3570
Content And Storage
4° C
Form
Liquid
Related Products
Description
- Description: Recognizes soluble and membranous human IL-6R
- This Antibody has been shown to inhibit IL-6 mediated proliferation of XG-1 cells, and partially blocks binding of IL-6 to its receptor
- BMS135 is applicable for FACS analysis IL-6 is a multifunctional cytokine involved in the regulation of the immune response, hematopoiesis and acute phase response
- It has been recognized to be a member of the alpha-helical cytokine family
- IL-6 exerts its action via a cell surface receptor which consists of two subunits, an 80 kDa ligand binding subunit (gp80) of 468 amino acids and a 130 kDa signal transducing protein (gp130) of 896 amino acid residues
- Characterisation of the extracellular portion of the 80 kDa IL-6 receptor revealed the existence of a single immunoglobulin-like domain in the NH2-terminal of the extracellular region, which does not contribute to ligand binding
- The remainder of the extracellular domain however is essential for low affinity ligand binding, which consecutively triggers the association of the receptor and gp130 thus forming a high affinity binding site for IL-6
- A soluble form of the human gp80 protein has been detected in serum and urine samples
- This 55 kDa protein representing the extracellular portion of gp80 is generated by shedding, a process that seems to be controlled by protein kinase C
- It is still functional, indicating that soluble gp80 plays a biological role in promoting IL-6 activity
- Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor
- This gene encodes a subunit of the interleukin 6 (IL6) receptor complex
- Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response
- The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines
- Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer
- Alternatively spliced transcript variants encoding distinct isoforms have been reported
- A pseudogene of this gene is found on chromosome 9.